Current projects and activities

Project type: Proof of Concept

Project status: 75% complete

Partners involved: Università Cattolica del Sacro Cuore, Imperial College London, Karolinska Institutet, University of Southampton

Problem: We don’t know if radiomics profiling can be used for severe asthma endotyping.

Fit with vision: Clarifying disease molecular mechanisms underlying severe asthma heterogeneity.

Concept: Assess if imaging outcomes (chest HRCT) relate to endotypes in severe asthma.

Successful outcome: Analysis report on correlations to U-BIOPRED dataset.

Next Steps: Publication and replicate in other datasets.

Project type: Proof of Concept

Project status: 30% complete

Partners involved: Breathomix, Università Cattolica del Sacro Cuore, Imperial College London, Karolinska Institutet, University of Southampton

Problem: The value of exhaled breath analysis has already been shown in multiple publications both for GC-MS and eNose. However, the value of the breathomics data collected in U-BIOPRED for phenotyping severe asthma patients has not been fully explored.

Fit with vision: Better understanding of the clinical value of the breathomics data can help improve the handprint of severe asthma patients.

Concept: Assess what patient clusters can be found based on breathomics data (eNOSE + GC/MS).

Successful outcome: Clinically relevant clusters/phenotypes..

Next Steps: Publication and present outcome in a Spotlight Session.

Project type: Proof of Concept

Project status: 15% complete

Partners involved: CIRO, Imperial College London, Karolinska Institutet

Problem: PRO’s don’t link well to physiological measurements but we do not know if they link well to OMIC signatures

Fit with vision: Link treatable mechanisms to patient centred outcomes

Concept: Reanalyse omic signatures (transcription-associated clusters (TACs)) in relation to PROs

Successful outcome: (New) Relationship(s) between certain OMIC signatures and PROs are identified.

Next Steps: Publication and present outcome in a Spotlight Session

Project type: Pilot

Project status: 45% complete

Partners involved: Università Cattolica del Sacro Cuore, Imperial College London, Karolinska Institutet, University of Southampton

Problem: We do not know if specific radiological profiles are linked with differences in physiological measures.

Fit with vision: Clarifying molecular heterogeneity in severe asthma

Concept: Assess if imaging outcomes (HRCT scans) link to physiological measure (and other measures) and if they relate to airway remodelling and/or airway inflammations

Successful outcome: Analysis report on U-BIOPRED data correlations

Next Steps: Publication and replicate in other datasets.

Project type: Proof of Concept

Project status: 5% complete

Partners involved: Università Cattolica del Sacro Cuore, Imperial College London, Karolinska Institutet, Amsterdam UMC

Problem: We do not know if severe asthma radiomic-associated clusters are linked to specific urinary and breath metabotypes.

Fit with vision: Maps accessible biomarkers to treatable mechanisms

Concept: Analyse existing data to see if imaging outcomes (HRCT scans) link to urinary and breath metabolomic endotypes and relate to airway remodelling

Successful outcome: Analysis report on U-BIOPRED data correlations

Next Steps: Publication and replicate in other datasets.